| First Author | Zha X | Year | 2021 |
| Journal | J Immunol | Volume | 206 |
| Issue | 9 | Pages | 2160-2169 |
| PubMed ID | 33863788 | Mgi Jnum | J:331147 |
| Mgi Id | MGI:6727238 | Doi | 10.4049/jimmunol.2000957 |
| Citation | Zha X, et al. (2021) IL-27/IL-27R Mediates Protective Immunity against Chlamydial Infection by Suppressing Excessive Th17 Responses and Reducing Neutrophil Inflammation. J Immunol 206(9):2160-2169 |
| abstractText | IL-27, a heterodimeric cytokine of the IL-12 family, has diverse influences on the development of multiple inflammatory diseases. In this study, we identified the protective role of IL-27/IL-27R in host defense against Chlamydia muridarum respiratory infection and further investigated the immunological mechanism. Our results showed that IL-27 was involved in C. muridarum infection and that IL-27R knockout mice (WSX-1(-/-) mice) suffered more severe disease, with greater body weight loss, higher chlamydial loads, and more severe inflammatory reactions in the lungs than C57BL/6 wild-type mice. There were excessive IL-17-producing CD4(+) T cells and many more neutrophils, neutrophil-related proteins, cytokines, and chemokines in the lungs of WSX-1(-/-) mice than in wild-type mice following C. muridarum infection. In addition, IL-17/IL-17A-blocking Ab treatment improved disease after C. muridarum infection in WSX-1(-/-) mice. Overall, we conclude that IL-27/IL-27R mediates protective immunity during chlamydial respiratory infection in mice by suppressing excessive Th17 responses and reducing neutrophil inflammation. |
