| First Author | Hill M | Year | 2021 |
| Journal | Dis Model Mech | Volume | 14 |
| Issue | 4 | PubMed ID | 33973623 |
| Mgi Jnum | J:304913 | Mgi Id | MGI:6696170 |
| Doi | 10.1242/dmm.047662 | Citation | Hill M, et al. (2021) miRNA interplay: mechanisms and consequences in cancer. Dis Model Mech 14(4) |
| abstractText | Canonically, microRNAs (miRNAs) control mRNA expression. However, studies have shown that miRNAs are also capable of targeting non-coding RNAs, including long non-coding RNAs and miRNAs. The latter, termed a miRNA:miRNA interaction, is a form of self-regulation. In this Review, we discuss the three main modes of miRNA:miRNA regulation: direct, indirect and global interactions, and their implications in cancer biology. We also discuss the cell-type-specific nature of miRNA:miRNA interactions, current experimental approaches and bioinformatic techniques, and how these strategies are not sufficient for the identification of novel miRNA:miRNA interactions. The self-regulation of miRNAs and their impact on gene regulation has yet to be fully understood. Investigating this hidden world of miRNA self-regulation will assist in discovering novel regulatory mechanisms associated with disease pathways. |
