| First Author | Lei L | Year | 2021 |
| Journal | J Cell Mol Med | Volume | 25 |
| Issue | 10 | Pages | 4870-4876 |
| PubMed ID | 33733611 | Mgi Jnum | J:343886 |
| Mgi Id | MGI:6719665 | Doi | 10.1111/jcmm.16465 |
| Citation | Lei L, et al. (2021) Med1 controls CD8 T cell maintenance through IL-7R-mediated cell survival signalling. J Cell Mol Med 25(10):4870-4876 |
| abstractText | Under steady-state conditions, the pool size of peripheral CD8(+) T cells is maintained through turnover and survival. Beyond TCR and IL-7R signals, the underlying mechanisms are less well understood. In the present study, we found a significant reduction of CD8(+) T cell proportion in spleens but not in thymi of mice with T cell-specific deletion of Mediator Subunit 1 (Med1). A competitive transfer of wild-type (WT) and Med1-deficient CD8(+) T cells reproduced the phenotype in the same recipients and confirmed intrinsic role of Med1. Furthermore, we observed a comparable degree of migration and proliferation but a significant increase of cell death in Med1-deficient CD8(+) T cells compared with WT counterparts. Finally, Med1-deficient CD8(+) T cells exhibited a decreased expression of interleukin-7 receptor alpha (IL-7Ralpha), down-regulation of phosphorylated-STAT5 (pSTAT5) and Bim up-regulation. Collectively, our study reveals a novel role of Med1 in the maintenance of CD8(+) T cells through IL-7Ralpha/STAT5 pathway-mediated cell survival. |
