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Publication : A shared transcriptional code orchestrates temporal patterning of the central nervous system.

First Author  Sagner A Year  2021
Journal  PLoS Biol Volume  19
Issue  11 Pages  e3001450
PubMed ID  34767545 Mgi Jnum  J:314775
Mgi Id  MGI:6828346 Doi  10.1371/journal.pbio.3001450
Citation  Sagner A, et al. (2021) A shared transcriptional code orchestrates temporal patterning of the central nervous system. PLoS Biol 19(11):e3001450
abstractText  The molecular mechanisms that produce the full array of neuronal subtypes in the vertebrate nervous system are incompletely understood. Here, we provide evidence of a global temporal patterning program comprising sets of transcription factors that stratifies neurons based on the developmental time at which they are generated. This transcriptional code acts throughout the central nervous system, in parallel to spatial patterning, thereby increasing the diversity of neurons generated along the neuraxis. We further demonstrate that this temporal program operates in stem cell-derived neurons and is under the control of the TGFbeta signaling pathway. Targeted perturbation of components of the temporal program, Nfia and Nfib, reveals their functional requirement for the generation of late-born neuronal subtypes. Together, our results provide evidence for the existence of a previously unappreciated global temporal transcriptional program of neuronal subtype identity and suggest that the integration of spatial and temporal patterning mechanisms diversifies and organizes neuronal subtypes in the vertebrate nervous system.
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