| First Author | Abu-Remaileh M | Year | 2015 |
| Journal | Exp Biol Med (Maywood) | Volume | 240 |
| Issue | 3 | Pages | 345-50 |
| PubMed ID | 25491415 | Mgi Jnum | J:312174 |
| Mgi Id | MGI:6783044 | Doi | 10.1177/1535370214561956 |
| Citation | Abu-Remaileh M, et al. (2015) The tumor suppressor WW domain-containing oxidoreductase modulates cell metabolism. Exp Biol Med (Maywood) 240(3):345-50 |
| abstractText | The WW domain-containing oxidoreductase (WWOX) encodes a tumor suppressor that is frequently altered in cancer. WWOX binds several proteins and thus is postulated to be involved in a variety of cellular processes. Interestingly, Wwox-knockout mice develop normally in utero but succumb to hypoglycemia and other metabolic defects early in life resulting in their death by 3-4 weeks of age. Cumulative evidence has linked WWOX with cellular metabolism including steroid metabolism, high-density lipoprotein cholesterol (HDL-C) metabolism, bone metabolism and, more recently, glucose metabolism. In this review, we discuss these evolving functions for WWOX and how its deletion affects cellular metabolism and neoplastic progression. |
