| First Author | Kong XW | Year | 2016 |
| Journal | Mol Reprod Dev | Volume | 83 |
| Issue | 11 | Pages | 1027-1040 |
| PubMed ID | 27696585 | Mgi Jnum | J:311226 |
| Mgi Id | MGI:6765094 | Doi | 10.1002/mrd.22744 |
| Citation | Kong XW, et al. (2016) Loss of function of KIF1B impairs oocyte meiotic maturation and early embryonic development in mice. Mol Reprod Dev 83(11):1027-1040 |
| abstractText | Kinesin family member 1B (KIF1B) is an important microtubule-dependent monomeric motor in mammals, although little is known about its role in meiosis. We profiled KIF1B expression and localization during oocyte maturation and early embryonic development in mice, revealing a dynamic pattern throughout meiotic progression. Depletion or inhibition of KIF1B leads to abnormal polar body extrusion, disordered spindle dynamics, defects in chromosome congression, increased aneuploidy, and impaired embryonic development. Further, KIF1B depletion affects the distribution of mitochondria and abundance of ATP. Taken together, our study demonstrates that mouse KIF1B is important for spindle assembly, chromosome congression, and mitochondrial distribution during oocyte maturation and early embryonic development. Mol. Reprod. Dev. 83: 1027-1040, 2016 (c) 2016 Wiley Periodicals, Inc. |
