| First Author | Cioffi M | Year | 2015 |
| Journal | Cell Rep | Volume | 12 |
| Issue | 10 | Pages | 1594-605 |
| PubMed ID | 26321631 | Mgi Jnum | J:315560 |
| Mgi Id | MGI:6829242 | Doi | 10.1016/j.celrep.2015.08.006 |
| Citation | Cioffi M, et al. (2015) MiR-93 Controls Adiposity via Inhibition of Sirt7 and Tbx3. Cell Rep 12(10):1594-605 |
| abstractText | Conquering obesity has become a major socioeconomic challenge. Here, we show that reduced expression of the miR-25-93-106b cluster, or miR-93 alone, increases fat mass and, subsequently, insulin resistance. Mechanistically, we discovered an intricate interplay between enhanced adipocyte precursor turnover and increased adipogenesis. First, miR-93 controls Tbx3, thereby limiting self-renewal in early adipocyte precursors. Second, miR-93 inhibits the metabolic target Sirt7, which we identified as a major driver of in vivo adipogenesis via induction of differentiation and maturation of early adipocyte precursors. Using mouse parabiosis, obesity in mir-25-93-106b(-/-) mice could be rescued by restoring levels of circulating miRNA and subsequent inhibition of Tbx3 and Sirt7. Downregulation of miR-93 also occurred in obese ob/ob mice, and this phenocopy of mir-25-93-106b(-/-) was partially reversible with injection of miR-93 mimics. Our data establish miR-93 as a negative regulator of adipogenesis and a potential therapeutic option for obesity and the metabolic syndrome. |
