| First Author | Chu M | Year | 2015 |
| Journal | Biomed Res Int | Volume | 2015 |
| Pages | 263630 | PubMed ID | 26783516 |
| Mgi Jnum | J:315391 | Mgi Id | MGI:6830324 |
| Doi | 10.1155/2015/263630 | Citation | Chu M, et al. (2015) Role of Baicalin in Anti-Influenza Virus A as a Potent Inducer of IFN-Gamma. Biomed Res Int 2015:263630 |
| abstractText | Baicalin (BA) is a flavonoid compound purified from Scutellaria baicalensis Georgi and has been shown to possess a potent inhibitory activity against viruses. However, the role of BA in anti-influenza virus has not been extensively studied, and the immunological mechanism of BA in antiviral activity remains unknown. Here, we observed that BA could protect mice from infection by influenza virus A/PR/8/34 (H1N1), associated with increasing IFN-gamma production, but presented no effects in IFN-gamma or IFN-gamma receptor deficient mice. Further study indicated that BA could inhibit A/PR/8/34 replication through IFN-gamma in human PBMC. Moreover, BA can directly induce IFN-gamma production in human CD4(+) and CD8(+) T cells and NK cells, and activate JAK/STAT-1 signaling pathway. Collectively, BA exhibited anti-influenza virus A (H1N1) activity in vitro and in vivo as a potent inducer of IFN-gamma in major IFN-gamma producing cells. |
