| First Author | Hou MS | Year | 2015 |
| Journal | J Autoimmun | Volume | 56 |
| Pages | 118-29 | PubMed ID | 25500198 |
| Mgi Jnum | J:329697 | Mgi Id | MGI:6822674 |
| Doi | 10.1016/j.jaut.2014.11.003 | Citation | Hou MS, et al. (2015) The interleukin-15 system suppresses T cell-mediated autoimmunity by regulating negative selection and nT(H)17 cell homeostasis in the thymus. J Autoimmun 56:118-29 |
| abstractText | The interleukin-15 (IL-15) system is important for regulating both innate and adaptive immune responses, however, its role in autoimmune disease remained unclear. Here we found that Il15(-/-) and Il15ra(-/-) mice spontaneously developed late-onset autoimmune phenotypes. CD4(+) T cells of the knockout mice showed elevated autoreactivity as demonstrated by the induction of lymphocyte infiltration in the lacrimal and salivary glands when transferred into nude mice. The antigen-presenting cells in the thymic medullary regions expressed IL-15 and IL-15Ralpha, whose deficiency resulted in insufficient negative selection and elevated number of natural IL-17A-producing CD4(+) thymocytes. These findings reveal previously unknown functions of the IL-15 system in thymocyte development, and thus a new layer of regulation in T cell-mediated autoimmunity. |
