| First Author | Bhat N | Year | 2021 |
| Journal | J Exp Med | Volume | 218 |
| Issue | 5 | PubMed ID | 33822844 |
| Mgi Jnum | J:343813 | Mgi Id | MGI:6724875 |
| Doi | 10.1084/jem.20200971 | Citation | Bhat N, et al. (2021) Regnase-1 is essential for B cell homeostasis to prevent immunopathology. J Exp Med 218(5) |
| abstractText | Regnase-1 is an emerging regulator of immune responses with essential roles in the posttranscriptional control of immune cell activation. Regnase-1 is expressed in B cells; however, its B cell-specific functions remain unknown. Here, we demonstrate that Regnase-1 prevents severe autoimmune pathology and show its essential role in maintaining B cell homeostasis. Using Cre driver mice for ablation of Regnase-1 at various stages of B cell development, we demonstrate that loss of Regnase-1 leads to aberrant B cell activation and differentiation, resulting in systemic autoimmunity and early morbidity. The basis of these findings was informed by gene expression data revealing a regulatory role for Regnase-1 in the suppression of a transcriptional program that promotes B cell activation, survival, and differentiation. Overall, our study shows that Regnase-1 exerts critical control of B cell activation, which is required for prevention of immunopathology. |
