| First Author | He DD | Year | 2020 |
| Journal | Stem Cell Reports | Volume | 14 |
| Issue | 4 | Pages | 614-630 |
| PubMed ID | 32220331 | Mgi Jnum | J:308976 |
| Mgi Id | MGI:6751763 | Doi | 10.1016/j.stemcr.2020.03.001 |
| Citation | He DD, et al. (2020) C-KIT Expression Distinguishes Fetal from Postnatal Skeletal Progenitors. Stem Cell Reports 14(4):614-630 |
| abstractText | Hematopoietic stem cells (HSCs) and skeletal stem cells (SSCs) cohabit in the bone marrow. KITL (C-KIT ligand) from LEPR(+) adult bone marrow stromal cells is pivotal for HSC maintenance. In contrast, it remains unclear whether KITL/C-KIT signaling also regulates SSCs. Here, we lineage traced C-KIT(+) cells and found that C-KIT was expressed by fetal, but not postnatal skeletal progenitors. Fetal C-KIT(+) cells gave rise to 20% of LEPR(+) stromal cells in adult bone marrow, forming nearly half of all osteoblasts. Disruption of mTOR signaling in fetal C-KIT(+) cells impaired bone formation. Notably, conditional deletion of Kitl from PRX1(+) fetal bone marrow stromal cells, but not LEPR(+) adult bone marrow stromal cells, significantly increased bone formation. Thus, our work identified C-KIT(+) skeletal progenitors as an important source of bones formed during development. |
