| First Author | Dai R | Year | 2021 |
| Journal | Front Immunol | Volume | 12 |
| Pages | 727046 | PubMed ID | 34691033 |
| Mgi Jnum | J:312704 | Mgi Id | MGI:6785695 |
| Doi | 10.3389/fimmu.2021.727046 | Citation | Dai R, et al. (2021) gammadeltaT Cells Are Required for CD8(+) T Cell Response to Vaccinia Viral Infection. Front Immunol 12:727046 |
| abstractText | Vaccinia virus (VV) is the most studied member of the poxvirus family, is responsible for the successful elimination of smallpox worldwide, and has been developed as a vaccine vehicle for infectious diseases and cancer immunotherapy. We have previously shown that the unique potency of VV in the activation of CD8(+) T cell response is dependent on efficient activation of the innate immune system through Toll-like receptor (TLR)-dependent and -independent pathways. However, it remains incompletely defined what regulate CD8(+) T cell response to VV infection. In this study, we showed that gammadeltaT cells play an important role in promoting CD8(+) T cell response to VV infection. We found that gammadeltaT cells can directly present viral antigens in the context of MHC-I for CD8(+) T cell activation to VV in vivo, and we further demonstrated that cell-intrinsic MyD88 signaling in gammadeltaT cells is required for activation of gammadeltaT cells and CD8(+) T cells. These results illustrate a critical role for gammadeltaT cells in the regulation of adaptive T cell response to viral infection and may shed light on the design of more effective vaccine strategies based on manipulation of gammadeltaT cells. |
