| First Author | Xu X | Year | 2017 |
| Journal | Cell Mol Immunol | Volume | 14 |
| Issue | 7 | Pages | 597-606 |
| PubMed ID | 27133471 | Mgi Jnum | J:331307 |
| Mgi Id | MGI:6838481 | Doi | 10.1038/cmi.2015.103 |
| Citation | Xu X, et al. (2017) Myeloid-derived suppressor cells promote B-cell production of IgA in a TNFR2-dependent manner. Cell Mol Immunol 14(7):597-606 |
| abstractText | Myeloid-derived suppressor cells (MDSCs) are well known for their capacity to suppress antitumor T-cell responses, but their effects on B-cell function and antibody production remain unclear. Here, we found that MDSCs that accumulated around the germinal center in the spleen of tumor-bearing mice co-located with B cells. In the presence of MDSCs, the antibody reaction to a surrogate antigen was significantly enhanced in mice, especially the immunoglobulin (Ig)A subtype. Co-culture with MDSCs promoted both proliferation and differentiation of B cells into IgA-producing plasma cells in vitro. Interestingly, the cross talk between MDSCs and B cells required cell-cell contact. MDSCs from tumor necrosis factor receptor (TNFR) 2(-/-) mice, but not from TNFR1(-/-) mice, failed to promote B-cell responses. Further investigation suggested that interleukin-10 and transforming growth factor-beta1 were crucial for the MDSC-mediated promotion of IgA responses. These results demonstrate a novel mechanism of MDSC-mediated immune regulation during tumor growth. |
