| First Author | Matalova E | Year | 2013 |
| Journal | Dev Growth Differ | Volume | 55 |
| Issue | 5 | Pages | 615-21 |
| PubMed ID | 23713787 | Mgi Jnum | J:316793 |
| Mgi Id | MGI:6840353 | Doi | 10.1111/dgd.12066 |
| Citation | Matalova E, et al. (2013) Caspase-7 participates in differentiation of cells forming dental hard tissues. Dev Growth Differ 55(5):615-21 |
| abstractText | Apoptosis during tooth development appears dependent on the apoptotic executioner caspase-3, but not caspase-7. Instead, activated caspase-7 has been found in differentiated odontoblasts and ameloblasts, where it does not correlate with apoptosis. To further investigate these findings, the mouse incisor was used as a model. Analysis of caspase-7-deficient mice revealed a significant thinner layer of hard tissue in the adult incisor. Micro computed tomography scan confirmed this decrease in mineralized tissues. These data strongly suggest that caspase-7 might be directly involved in functional cell differentiation and regulation of the mineralization of dental matrices. |
