| First Author | Serrano-Candelas E | Year | 2015 |
| Journal | Biochem Biophys Res Commun | Volume | 460 |
| Issue | 2 | Pages | 295-301 |
| PubMed ID | 25783055 | Mgi Jnum | J:309990 |
| Mgi Id | MGI:6760262 | Doi | 10.1016/j.bbrc.2015.03.029 |
| Citation | Serrano-Candelas E, et al. (2015) RCAN 1 and 3 proteins regulate thymic positive selection. Biochem Biophys Res Commun 460(2):295-301 |
| abstractText | Cooperation between calcineurin (CN)-NFATc and RAF-MEK-ERK signaling pathways is essential in thymocyte positive selection. It is known that the Regulators of Calcineurin (RCAN) proteins can act either facilitating or suppressing CN-dependent signaling events. Here, we show that RCAN genes are expressed in lymphoid tissues, and address the role of RCAN proteins in T cell development. Overexpression of human RCAN3 and RCAN1 can modulate T cell development by increasing positive selection-related surface markers, as well as the "Erk(hi) competence state" in double positive thymocytes, a characteristic molecular signature of positive selection, without affecting CN activity. We also found that RCAN1/3 interact with RAF kinases and CN in a non-exclusive manner. Our data suggests that the balance of RCAN interactions with CN and/or RAF kinases may influence T cell positive selection. |
