| First Author | Salinas GF | Year | 2012 |
| Journal | J Neuroimmunol | Volume | 250 |
| Issue | 1-2 | Pages | 35-43 |
| PubMed ID | 22688423 | Mgi Jnum | J:318930 |
| Mgi Id | MGI:6861977 | Doi | 10.1016/j.jneuroim.2012.05.012 |
| Citation | Salinas GF, et al. (2012) Sustained Rap1 activation in autoantigen-specific T lymphocytes attenuates experimental autoimmune encephalomyelitis. J Neuroimmunol 250(1-2):35-43 |
| abstractText | Altered Ras superfamily guanine nucleotide triphosphatase signaling may contribute to the activation of autoreactive T cells in diseases such as rheumatoid arthritis and systemic lupus erythematosus. Here, we show that transgenic expression of activated Rap1, a Ras-related protein which is protective in murine arthritis, in both wildtype (WT) and 2D2 mice, enhances autoreactive T cell activation by myelin oligodendrocyte glycoprotein peptide in vitro and in vivo. However, RapV12 reduces the number of autoreactive T cells in both WT and 2D2 mice, and increases murine survival in experimental autoimmune encephalitis, suggesting Rap1 activation restricts autoimmune T cell-mediated pathology through enhancing tolerance. |
