| First Author | Amarilyo G | Year | 2014 |
| Journal | J Immunol | Volume | 193 |
| Issue | 2 | Pages | 540-3 |
| PubMed ID | 24920843 | Mgi Jnum | J:319344 |
| Mgi Id | MGI:6862550 | Doi | 10.4049/jimmunol.1400931 |
| Citation | Amarilyo G, et al. (2014) IL-17 promotes murine lupus. J Immunol 193(2):540-3 |
| abstractText | The proinflammatory activity of IL-17-producing Th17 cells has been associated with the pathogenesis of several autoimmune diseases. In this article, we provide direct evidence for a role of IL-17 in the pathogenesis of systemic lupus erythematosus (SLE). The induction of SLE by pristane in IL-17-sufficient wild-type mice did not occur in IL-17-deficient mice, which were protected from development of lupus autoantibodies and glomerulonephritis. The protection from SLE in IL-17-deficient mice was associated with a reduced frequency of CD3(+)CD4(-)CD8(-) double-negative T cells and an expansion of CD4(+) regulatory T cells, and did not depend on Stat-1 signaling. These data affirm the key role of IL-17 in the pathogenesis of SLE and strengthen the support for IL-17 blockade in the therapy of SLE. |
