| First Author | Kim JA | Year | 2016 |
| Journal | Muscle Nerve | Volume | 53 |
| Issue | 2 | Pages | 287-96 |
| PubMed ID | 26044200 | Mgi Jnum | J:319144 |
| Mgi Id | MGI:6862886 | Doi | 10.1002/mus.24723 |
| Citation | Kim JA, et al. (2016) PPARdelta preserves a high resistance to fatigue in the mouse medial gastrocnemius after spinal cord transection. Muscle Nerve 53(2):287-96 |
| abstractText | INTRODUCTION: Skeletal muscle oxidative capacity decreases and fatigability increases after spinal cord injury. Transcription factor peroxisome proliferator-activated receptor delta (PPARdelta) promotes a more oxidative phenotype. METHODS: We asked whether PPARdelta overexpression could ameliorate these deficits in the medial gastrocnemius of spinal cord transected (ST) adult mice. RESULTS: Time-to-peak tension and half-relaxation times were longer in PPARdelta-Con and PPARdelta-ST compared with littermate wild-type (WT) controls. Fatigue index was 50% higher in PPARdelta-Con than WT-Con and 70% higher in the PPARdelta-ST than WT-ST. There was an overall higher percent of darkly stained fibers for succinate dehydrogenase in both PPARdelta groups. CONCLUSIONS: The results indicate a conversion toward slower, more oxidative, and less fatigable muscle properties with overexpression of PPARdelta. Importantly, the elevated fatigue resistance was maintained after ST, suggesting that enhanced PPARdelta expression, and possibly small molecule agonists, could ameliorate the increased fatigability routinely observed in chronically paralyzed muscles. |
