| First Author | Regelin M | Year | 2015 |
| Journal | J Immunol | Volume | 195 |
| Issue | 10 | Pages | 4832-40 |
| PubMed ID | 26475928 | Mgi Jnum | J:319157 |
| Mgi Id | MGI:6862943 | Doi | 10.4049/jimmunol.1402248 |
| Citation | Regelin M, et al. (2015) Responsiveness of Developing T Cells to IL-7 Signals Is Sustained by miR-17 approximately 92. J Immunol 195(10):4832-40 |
| abstractText | miRNAs regulate a large variety of developmental processes including development of the immune system. T cell development is tightly controlled through the interplay of transcriptional programs and cytokine-mediated signals. However, the role of individual miRNAs in this process remains largely elusive. In this study, we demonstrated that hematopoietic cell-specific loss of miR-17 approximately 92, a cluster of six miRNAs implicated in B and T lineage leukemogenesis, resulted in profound defects in T cell development both at the level of prethymic T cell progenitors as well as intrathymically. We identified reduced surface expression of IL-7R and concomitant limited responsiveness to IL-7 signals as a common mechanism resulting in reduced cell survival of common lymphoid progenitors and thymocytes at the double-negative to double-positive transition. In conclusion, we identified miR-17 approximately 92 as a critical modulator of multiple stages of T cell development. |
