| First Author | Ifergan I | Year | 2016 |
| Journal | J Immunol | Volume | 196 |
| Issue | 4 | Pages | 1455-1459 |
| PubMed ID | 26783338 | Mgi Jnum | J:319166 |
| Mgi Id | MGI:6862975 | Doi | 10.4049/jimmunol.1501965 |
| Citation | Ifergan I, et al. (2016) Cutting Edge: MicroRNA-223 Regulates Myeloid Dendritic Cell-Driven Th17 Responses in Experimental Autoimmune Encephalomyelitis. J Immunol 196(4):1455-1459 |
| abstractText | Myeloid cells play a crucial role in the induction and sustained inflammation in neuroinflammatory disorders, such as multiple sclerosis. miR-223, a myeloid cell-specific microRNA, is one of the most upregulated microRNAs in multiple sclerosis patients. We demonstrate that miR-223-knockout mice display significantly reduced active and adoptive-transfer experimental autoimmune encephalomyelitis that is characterized by reduced numbers of myeloid dendritic cells (mDCs) and Th17 cells in the CNS. Knockout mDCs have increased PD-L1 and decreased IL-1beta, IL-6, and IL-23 expression, as well as a reduced capacity to drive Th17, but not Th1, cell differentiation. Thus, miR-223 controls mDC-induced activation of pathologic Th17 responses during autoimmune inflammation. |
