| First Author | Lindstad CB | Year | 2021 |
| Journal | PLoS One | Volume | 16 |
| Issue | 11 | Pages | e0259082 |
| PubMed ID | 34731200 | Mgi Jnum | J:312926 |
| Mgi Id | MGI:6792277 | Doi | 10.1371/journal.pone.0259082 |
| Citation | Lindstad CB, et al. (2021) TG2-gluten complexes as antigens for gluten-specific and transglutaminase-2 specific B cells in celiac disease. PLoS One 16(11):e0259082 |
| abstractText | A hallmark of celiac disease is the gluten-dependent production of antibodies specific for deamidated gluten peptides (DGP) and the enzyme transglutaminase 2 (TG2). Both types of antibodies are believed to result from B cells receiving help from gluten-specific CD4+ T cells and differentiating into antibody-producing plasma cells. We have here studied the collaboration between DGP- and TG2-specific B cells with gluten-specific CD4+ T cells using transgenic mice expressing celiac patient-derived T-cell and B-cell receptors, as well as between B-cell transfectants and patient-derived gluten-specific T-cell clones. We show that multivalent TG2-gluten complexes are efficient antigens for both TG2-specific and DGP-specific B cells and allow both types of B cells to receive help from gluten-specific T cells of many different specificities. |
