| First Author | Mamonkin M | Year | 2013 |
| Journal | Immunol Lett | Volume | 156 |
| Issue | 1-2 | Pages | 94-101 |
| PubMed ID | 24075846 | Mgi Jnum | J:318201 |
| Mgi Id | MGI:6858737 | Doi | 10.1016/j.imlet.2013.09.008 |
| Citation | Mamonkin M, et al. (2013) Differential roles of KLF4 in the development and differentiation of CD8+ T cells. Immunol Lett 156(1-2):94-101 |
| abstractText | The transcription factor Kruppel-like factor 4 (KLF4) can activate or repress gene expression in a cell-context dependent manner. We have previously shown that KLF4 inhibits the proliferation of naive CD8(+) T cells in vitro downstream of the transcription factor ELF4. In this work, we describe a novel role of KLF4 in the differentiation of CD8(+) T cells upon infection. Loss of KLF4 had minimal effect on thymic T cell development and distribution of mature T cells in the spleen, blood, and lymph nodes. KLF4-deficient naive CD8(+) T cells also displayed normal homeostatic proliferation upon adoptive transfer into lymphopenic hosts. However, activation of KLF4-deficient naive CD8(+) T cells by in vitro TCR crosslink and co-stimulation resulted in increased proliferation. Furthermore, naive KLF4-deficient OT-I CD8(+) T cells generated increased numbers of functional memory CD8(+) T cells compared to wild type OT-I CD8(+) T cells co-injected in the same recipient in both primary and recall responses to Listeria monocytogenes-OVA. Collectively, our data demonstrate that KLF4 regulates differentiation of functional memory CD8(+) T cells while sparing development and homeostasis of naive CD8(+) T cells. |
