| First Author | Cepero-Donates Y | Year | 2016 |
| Journal | Cytokine | Volume | 82 |
| Pages | 95-101 | PubMed ID | 26778709 |
| Mgi Jnum | J:318338 | Mgi Id | MGI:6859267 |
| Doi | 10.1016/j.cyto.2015.12.012 | Citation | Cepero-Donates Y, et al. (2016) Homeostasis of IL-15 dependent lymphocyte subsets in the liver. Cytokine 82:95-101 |
| abstractText | IL-15 is a member of the gamma chain family of cytokines (gammac - CD132). The IL-15 receptor (IL-15R) complex consists of 3 subunits: the ligand-binding IL-15Ralpha chain (CD215), the beta chain (CD122; also used by IL-2), and the common gamma chain. The biological activities of IL-15 are mostly mediated by the IL-15:IL-15Ralpha complex, produced by the same cell and 'trans-presented' to responder cells expressing the IL-15Rbetagammac. The peculiar and almost unique requirement for IL-15 to be trans-presented by IL-15Ralpha suggests that the biological effects of IL-15 signaling are tightly regulated even at the level of availability of IL-15. Tissue-specific deletion of IL-15Ralpha has shown macrophage-and dendritic cell-derived IL-15Ralpha mediate the homeostasis of different CD8(+) T cell subsets. Here we show that hepatocyte and macrophage- specific expression of IL-15Ralpha is required to maintain the homeostasis of NK and NKT cells in the liver. Thus, homeostasis of IL-15-dependent lymphocyte subsets is also regulated by trans-presentation of IL-15 by non-hematopoietic cells in the tissue environment. |
