| First Author | Senger K | Year | 2017 |
| Journal | Exp Hematol | Volume | 55 |
| Pages | 45-55 | PubMed ID | 28751190 |
| Mgi Jnum | J:318433 | Mgi Id | MGI:6859618 |
| Doi | 10.1016/j.exphem.2017.07.005 | Citation | Senger K, et al. (2017) Septin 6 regulates engraftment and lymphoid differentiation potential of murine long-term hematopoietic stem cells. Exp Hematol 55:45-55 |
| abstractText | Septins are a family of filament-forming GTP-binding proteins that serve as scaffolds and diffusion barriers in various cellular processes. Septin 6 is known as a fusion partner of mixed-lineage leukemia in infant acute myeloid leukemia. The occurrence of the fusion gene is associated with a reduced expression of septin 6 itself. The role of septin 6 in hematopoiesis and whether it is involved in scaffolds within hematopoietic cells is not known. Septin 6-deficient hematopoietic stem cells (HSCs) present with an increased engraftment potential but altered lymphoid differentiation with a reduced contribution to the T-cell compartment and an increased B-cell contribution. Although multipotent progenitor cells showed a very distinct septin 6 filament organization and intracellular distribution, their function was not impaired by septin 6 deficiency. Our data therefore suggest a regulatory role for septin 6 in long-term HSC function and lymphoid lineage differentiation. |
