| First Author | Azimi E | Year | 2017 |
| Journal | J Allergy Clin Immunol | Volume | 140 |
| Issue | 2 | Pages | 447-453.e3 |
| PubMed ID | 28219706 | Mgi Jnum | J:318459 |
| Mgi Id | MGI:6859745 | Doi | 10.1016/j.jaci.2016.12.980 |
| Citation | Azimi E, et al. (2017) Substance P activates Mas-related G protein-coupled receptors to induce itch. J Allergy Clin Immunol 140(2):447-453.e3 |
| abstractText | BACKGROUND: Substance P (SP) is linked to itch and inflammation through activation of receptors on mast cells and sensory neurons. There is increasing evidence that SP functions through Mas-related G protein-coupled receptors (Mrgprs) in addition to its conventional receptor, neurokinin-1. OBJECTIVE: Because Mrgprs mediate some aspects of inflammation that had been considered mediated by neurokinin-1 receptor (NK-1R), we sought to determine whether itch induced by SP can also be mediated by Mrgprs. METHODS: Genetic and pharmacologic approaches were used to evaluate the contribution of Mrgprs to SP-induced scratching behavior and activation of cultured dorsal root ganglion neurons from mice. RESULTS: SP-induced scratching behavior and activation of cultured dorsal root ganglion neurons was dependent on Mrgprs rather than NK-1R. CONCLUSION: We deduce that SP activates MrgprA1 on sensory neurons rather than NK-1R to induce itch. |
