| First Author | Bol'shakova AV | Year | 2017 |
| Journal | Bull Exp Biol Med | Volume | 164 |
| Issue | 2 | Pages | 252-258 |
| PubMed ID | 29177899 | Mgi Jnum | J:318486 |
| Mgi Id | MGI:6859852 | Doi | 10.1007/s10517-017-3968-7 |
| Citation | Bol'shakova AV, et al. (2017) Neuroprotective Effect of sigma1-Receptors on the Cell Model of Huntington's Disease. Bull Exp Biol Med 164(2):252-258 |
| abstractText | Huntington's disease is a hereditary neurodegenerative disease that primarily affects striatal neurons. Recent studies demonstrated abnormalities in calcium regulation in striatal neurons in Huntington's disease, which leads to elimination of synaptic connections between cortical and striatal neurons. In the present study, we focused on the neuroprotective properties of sigma1-receptor, because one of its main functions is associated with modulation of calcium homeostasis in cells. The application of selective sigma1-receptor agonists to the corticostriatal cell culture restores synaptic connections between the cortical and striatal neurons. Based on the obtained data, we assume that sigma1-receptor is a promising target for the development of drugs for the therapy of Huntington's disease. |
