| First Author | Stieglitz D | Year | 2019 |
| Journal | Oncogene | Volume | 38 |
| Issue | 5 | Pages | 609-621 |
| PubMed ID | 30171260 | Mgi Jnum | J:317898 |
| Mgi Id | MGI:6860088 | Doi | 10.1038/s41388-018-0475-x |
| Citation | Stieglitz D, et al. (2019) BMP6-induced modulation of the tumor micro-milieu. Oncogene 38(5):609-621 |
| abstractText | Melanoma is the deadliest form of skin cancer with rising incidence, creating a significant health problem. We discovered increased expression of bone morphogenetic protein 6 (BMP6) in melanoma cells and tissues, and observed that BMP6 deficiency caused significantly delayed tumor onset and decelerated tumor progression in a melanoma mouse model. Moreover, we determined that BMP6 inhibits dermal mast cell recruitment and found that mast cell-derived mediators significantly reduced melanoma growth in vitro. In line with this, mast cell deficiency accelerated tumor onset and progression in a melanoma mouse model. Analysis of human melanoma tissues revealed a strong negative correlation between melanoma proliferation and mast cell infiltration. This study elucidates a novel role of BMP6-induced modulation of the tumor microenvironment. |
