Other
13 Authors
- Zhao C,
- Yang Z,
- Sun R,
- Zhao A,
- Xie Y,
- Grinchuk V,
- Pei C,
- Wang AJ,
- Fan AX,
- Shea-Donohue T,
- Lu N,
- Urban JF Jr,
- Smith A
| First Author | Pei C | Year | 2016 |
| Journal | Infect Immun | Volume | 84 |
| Issue | 12 | Pages | 3328-3337 |
| PubMed ID | 27620722 | Mgi Jnum | J:331000 |
| Mgi Id | MGI:6869374 | Doi | 10.1128/IAI.00180-16 |
| Citation | Pei C, et al. (2016) Critical Role for Interleukin-25 in Host Protective Th2 Memory Response against Heligmosomoides polygyrus bakeri. Infect Immun 84(12):3328-3337 |
| abstractText | Infection with parasitic nematodes, especially gastrointestinal geohelminths, affects hundreds of millions of people worldwide and thus poses a major risk to global health. The host mechanism of defense against enteric nematode infection remains to be fully understood, but it involves a polarized type 2 immunity leading to alterations in intestinal function that facilitate worm expulsion. We investigated the role of interleukin-25 (IL-25) in host protection against Heligmosomoides polygyrus bakeri infection in mice. Our results showed that Il25 and its receptor subunit, Il17rb, were upregulated during a primary infection and a secondary challenge infection with H. polygyrus bakeri Genetic deletion of IL-25 (IL-25(-/-)) led to an attenuated type 2 cytokine response and increased worm fecundity in mice with a primary H. polygyrus bakeri infection. In addition, the full spectrum of the host memory response against a secondary infection with H. polygyrus bakeri was severely impaired in IL-25(-/-) mice, including delayed type 2 cytokine responses, an attenuated functional response of the intestinal smooth muscle and epithelium, diminished intestinal smooth muscle hypertrophy/hyperplasia, and impaired worm expulsion. Furthermore, exogenous administration of IL-25 restored the host protective memory response against H. polygyrus bakeri infection in IL-25(-/-) mice. These data demonstrate that IL-25 is critical for host protective immunity against H. polygyrus bakeri infection, highlighting its potential application as a therapeutic agent against parasitic nematode infection worldwide. |
