| First Author | Lubeck BA | Year | 2015 |
| Journal | J Immunol | Volume | 195 |
| Issue | 1 | Pages | 31-5 |
| PubMed ID | 26002977 | Mgi Jnum | J:320357 |
| Mgi Id | MGI:6871240 | Doi | 10.4049/jimmunol.1402639 |
| Citation | Lubeck BA, et al. (2015) Cutting Edge: Codeletion of the Ras GTPase-Activating Proteins (RasGAPs) Neurofibromin 1 and p120 RasGAP in T Cells Results in the Development of T Cell Acute Lymphoblastic Leukemia. J Immunol 195(1):31-5 |
| abstractText | Ras GTPase-activating proteins (RasGAPs) inhibit signal transduction initiated through the Ras small GTP-binding protein. However, which members of the RasGAP family act as negative regulators of T cell responses is not completely understood. In this study, we investigated potential roles for the RasGAPs RASA1 and neurofibromin 1 (NF1) in T cells through the generation and analysis of T cell-specific RASA1 and NF1 double-deficient mice. In contrast to mice lacking either RasGAP alone in T cells, double-deficient mice developed T cell acute lymphoblastic leukemia/lymphoma, which originated at an early point in T cell development and was dependent on activating mutations in the Notch1 gene. These findings highlight RASA1 and NF1 as cotumor suppressors in the T cell lineage. |
