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Publication : Cell cycle regulation of embryonic stem cells and mouse embryonic fibroblasts lacking functional Pax7.

First Author  Czerwinska AM Year  2016
Journal  Cell Cycle Volume  15
Issue  21 Pages  2931-2942
PubMed ID  27610933 Mgi Jnum  J:320426
Mgi Id  MGI:6873408 Doi  10.1080/15384101.2016.1231260
Citation  Czerwinska AM, et al. (2016) Cell cycle regulation of embryonic stem cells and mouse embryonic fibroblasts lacking functional Pax7. Cell Cycle 15(21):2931-2942
abstractText  The transcription factor Pax7 plays a key role during embryonic myogenesis and in adult organisms in that it sustains the proper function of satellite cells, which serve as adult skeletal muscle stem cells. Recently we have shown that lack of Pax7 does not prevent the myogenic differentiation of pluripotent stem cells. In the current work we show that the absence of functional Pax7 in differentiating embryonic stem cells modulates cell cycle facilitating their proliferation. Surprisingly, deregulation of Pax7 function also positively impacts at the proliferation of mouse embryonic fibroblasts. Such phenotypes seem to be executed by modulating the expression of positive cell cycle regulators, such as cyclin E.
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