| First Author | Montalban-Arques A | Year | 2021 |
| Journal | Cell Host Microbe | Volume | 29 |
| Issue | 10 | Pages | 1573-1588.e7 |
| PubMed ID | 34453895 | Mgi Jnum | J:320615 |
| Mgi Id | MGI:6874697 | Doi | 10.1016/j.chom.2021.08.001 |
| Citation | Montalban-Arques A, et al. (2021) Commensal Clostridiales strains mediate effective anti-cancer immune response against solid tumors. Cell Host Microbe 29(10):1573-1588.e7 |
| abstractText | Despite overall success, T cell checkpoint inhibitors for cancer treatment are still only efficient in a minority of patients. Recently, intestinal microbiota was found to critically modulate anti-cancer immunity and therapy response. Here, we identify Clostridiales members of the gut microbiota associated with a lower tumor burden in mouse models of colorectal cancer (CRC). Interestingly, these commensal species are also significantly reduced in CRC patients compared with healthy controls. Oral application of a mix of four Clostridiales strains (CC4) in mice prevented and even successfully treated CRC as stand-alone therapy. This effect depended on intratumoral infiltration and activation of CD8(+) T cells. Single application of Roseburia intestinalis or Anaerostipes caccae was even more effective than CC4. In a direct comparison, the CC4 mix supplementation outperformed anti-PD-1 therapy in mouse models of CRC and melanoma. Our findings provide a strong preclinical foundation for exploring gut bacteria as novel stand-alone therapy against solid tumors. |
