| First Author | Lee AY | Year | 2017 |
| Journal | Anticancer Res | Volume | 37 |
| Issue | 5 | Pages | 2381-2386 |
| PubMed ID | 28476804 | Mgi Jnum | J:321177 |
| Mgi Id | MGI:6884222 | Doi | 10.21873/anticanres.11576 |
| Citation | Lee AY, et al. (2017) Knockdown of Importin 7 Inhibits Lung Tumorigenesis in K-ras(LA1) Lung Cancer Mice. Anticancer Res 37(5):2381-2386 |
| abstractText | Background/Aim: Lung cancer shows the highest estimated deaths in both males and females in the Unites States. Importin 7 is overexpressed in lung adenocarcinoma tissues. In this study, we aimed to demonstrate the anticancer effect of importin 7 down-regulation, especially in lung cancer. Materials and Methods: Glycerol propoxylate triacrylate spermine (GPT-SPE) is a biocompatible carrier used for aerosol gene delivery. Repeated aerosol delivery of GPT-SPE/shImportin 7 complexes was performed to 10-week-old male K-ras(LA1)mice (a murine lung cancer model) twice a week for 4 weeks (8 times) in a nose-only exposure chamber. Results: Aerosol delivery of GPT-SPE/shImportin 7 inhibits lung cancer in K-ras(LA1)mice compared to control and scramble control groups. Moreover, importin 7-down-regulated stable cell-line demonstrates suppression of proliferation through Akt inhibition and apoptosis. Conclusion: Down-regulation of importin 7 significantly suppresses lung cancer in vitro and in vivo. |
