| First Author | Rooney AM | Year | 2022 |
| Journal | Bone | Volume | 158 |
| Pages | 116349 | PubMed ID | 35123146 |
| Mgi Jnum | J:321543 | Mgi Id | MGI:6885314 |
| Doi | 10.1016/j.bone.2022.116349 | Citation | Rooney AM, et al. (2022) Bone mass and adaptation to mechanical loading are sexually dimorphic in adult osteoblast-specific ERalpha knockout mice. Bone 158:116349 |
| abstractText | Estrogen receptor-alpha (ERalpha) regulates bone mass and is implicated in bone tissue's response to mechanical loading. The effects of ERalpha deletion in mice depend on sex, anatomical location, and the cellular stage at which ERalpha is removed. Few studies have investigated the effect of age on the role of ERalpha in skeletal maintenance and functional adaptation. We previously demonstrated that bone mass and adaptation to loading were altered in growing 10-week-old female and male mice lacking ERalpha in mature osteoblasts and osteocytes (pOC-ERalphaKO). Here our goal was to determine the effects of ERalpha and mechanical loading in skeletally-mature adult mice. We subjected 26-week-old skeletally-mature adult pOC-ERalphaKO and littermate control (LC) mice of both sexes to two weeks of in vivo cyclic tibial loading. ERalpha deletion in male mice did not alter bone mass or the response to loading. Adult female pOC-ERalphaKO mice had reduced cancellous and cortical bone mass and increased adaptation to high-magnitude mechanical loading compared to LC mice. Thus, ERalpha deletion from mature osteoblasts reduced the bone mass and increased the mechanoadaptation of adult female but not male mice. Additionally, compared to our previous work in young mice, adult female mice had greatly reduced mechanoadaptation and adult male mice retained most of their mechanoadaptation with age. |
