| First Author | Wang YN | Year | 2022 |
| Journal | Front Cell Dev Biol | Volume | 10 |
| Pages | 852561 | PubMed ID | 35493107 |
| Mgi Jnum | J:324242 | Mgi Id | MGI:7275452 |
| Doi | 10.3389/fcell.2022.852561 | Citation | Wang YN, et al. (2022) The Role of Syncytin in Placental Angiogenesis and Fetal Growth. Front Cell Dev Biol 10:852561 |
| abstractText | Background: Syncytin, a retroviral envelope protein, is specifically expressed on trophoblast cells and mediates formation of the syncytiotrophoblast through fusogenic activity. Decreased expression of Syncytin was found in fetal growth restriction placentas. Results: By generating an inducible knockout of the syncytin-a gene in mice, we show a specific disruption of placental angiogenesis with abnormal formation of two syncytiotrophoblast layers. Consistent with the defects observed in vivo, conditioned medium collected from trophoblast cells, following Syncytin-1 knockdown, contains lower expression of vascular endothelial growth factor and placental growth factor, and higher levels of soluble fms-like protein kinase-1 in BeWo and HTR-8/SVneo cells which related with suppressed PI3K/Akt/mTOR pathway, and is reduced in ability to induce tube formation by HUVECs. Conclusion: Syncytin participates in angiogenesis during placental development was first identified both in vivo and in vitro. Here, we give a new sight on understanding syncytin and pathophysiology of placenta related disease such as fetal growth restriction. |
