| First Author | Sun H | Year | 2021 |
| Journal | Genes Brain Behav | Volume | 20 |
| Issue | 8 | Pages | e12771 |
| PubMed ID | 34672089 | Mgi Jnum | J:322407 |
| Mgi Id | MGI:7258203 | Doi | 10.1111/gbb.12771 |
| Citation | Sun H, et al. (2021) iRhom1 rescues cognitive dysfunction in multiple sclerosis via preventing myelin injury. Genes Brain Behav 20(8):e12771 |
| abstractText | Multiple sclerosis (MS) is characterized by myelin sheath injury. A disintegrin and metalloprotease-17 (ADAM17), a disintegrin and metalloproteinase, is essential in regulating oligodendrocyte (OL) regeneration and remyelination under demyelinating conditions. iRhom1, a highly conserved inactive protease that belongs to the rhomboid family, is one of key regulators for ADAM17 maturation. However, it is unknown whether iRhom1 also plays a role in central neuron system myelination under demyelinating conditions like MS. In this study, we investigated the function of iRhom1/ADAM17 in cognitive capability in MS by establishing the mice with iRhom1 overexpression in the hippocampus. |
