| First Author | Zheng L | Year | 2022 |
| Journal | Science | Volume | 376 |
| Issue | 6596 | Pages | 996-1001 |
| PubMed ID | 35617401 | Mgi Jnum | J:342796 |
| Mgi Id | MGI:7285998 | Doi | 10.1126/science.aaz8658 |
| Citation | Zheng L, et al. (2022) The CD8alpha-PILRalpha interaction maintains CD8(+) T cell quiescence. Science 376(6596):996-1001 |
| abstractText | T cell quiescence is essential for maintaining a broad repertoire against a large pool of diverse antigens from microbes and tumors, but the underlying molecular mechanisms remain largely unknown. We show here that CD8alpha is critical for the maintenance of CD8(+) T cells in a physiologically quiescent state in peripheral lymphoid organs. Upon inducible deletion of CD8alpha, both naive and memory CD8(+) T cells spontaneously acquired activation phenotypes and subsequently died without exposure to specific antigens. PILRalpha was identified as a ligand for CD8alpha in both mice and humans, and disruption of this interaction was able to break CD8(+) T cell quiescence. Thus, peripheral T cell pool size is actively maintained by the CD8alpha-PILRalpha interaction in the absence of antigen exposure. |
