| First Author | Cheng L | Year | 2022 |
| Journal | J Immunol | Volume | 209 |
| Issue | 3 | Pages | 456-464 |
| PubMed ID | 35831018 | Mgi Jnum | J:344986 |
| Mgi Id | MGI:7345990 | Doi | 10.4049/jimmunol.2101195 |
| Citation | Cheng L, et al. (2022) Carma3 Protects from Liver Injury by Preserving Mitochondrial Integrity in Liver Sinusoidal Endothelial Cells. J Immunol 209(3):456-464 |
| abstractText | Carma3 is an intracellular scaffolding protein that can form complex with Bcl10 and Malt1 to mediate G protein-coupled receptor- or growth factor receptor-induced NF-kappaB activation. However, the in vivo function of Carma3 has remained elusive. Here, by establishing a Con A-induced autoimmune hepatitis model, we show that liver injury is exacerbated in Carma3 (-/-) mice. Surprisingly, we find that the Carma3 expression level is higher in liver sinusoidal endothelial cells (LSECs) than in hepatocytes in the liver. In Carma3 (-/-) mice, Con A treatment induces more LSEC damage, accompanied by severer coagulation. In vitro we find that Carma3 localizes at mitochondria and Con A treatment can trigger more mitochondrial damage and cell death in Carma3-deficient LSECs. Taken together, our data uncover an unrecognized role of Carma3 in maintaining LSEC integrity, and these results may extend novel strategies to prevent liver injury from toxic insults. |
