| First Author | Ren T | Year | 2021 |
| Journal | FEBS J | Volume | 288 |
| Issue | 14 | Pages | 4364-4381 |
| PubMed ID | 33492759 | Mgi Jnum | J:329403 |
| Mgi Id | MGI:7344221 | Doi | 10.1111/febs.15725 |
| Citation | Ren T, et al. (2021) ID1 inhibits foot-and-mouth disease virus replication via targeting of interferon pathways. FEBS J 288(14):4364-4381 |
| abstractText | Inhibitor of DNA-binding 1 (ID1) protein has been studied intensively for its functions in tumorigenesis and maintenance of stem cell-like properties, but its roles in virus infection are less understood. In the present study, we have clearly shown that the foot-and-mouth disease virus (FMDV) promotes ID1 degradation via Cdh1-mediated ubiquitination to facilitate its replication. Mechanistic investigations reveal Forkhead Box O1 (FOXO1) as an ID1 partner, which suppresses interferon regulatory factors 3 expression and interferon (IFN) production. Further investigation identified that ID1 suppresses FOXO1 transcription activity through HDAC4-mediated deacetylation, promoting IFN production and antiviral immune response. These studies establish a prominent role for ID1 in suppressing FDMV replication, which may be extended to other viruses. |
