| First Author | Okuda S | Year | 2022 |
| Journal | Int J Mol Sci | Volume | 23 |
| Issue | 21 | PubMed ID | 36362177 |
| Mgi Jnum | J:334182 | Mgi Id | MGI:7385742 |
| Doi | 10.3390/ijms232113390 | Citation | Okuda S, et al. (2022) Striatal-Inoculation of alpha-Synuclein Preformed Fibrils Aggravated the Phenotypes of REM Sleep without Atonia in A53T BAC-SNCA Transgenic Mice. Int J Mol Sci 23(21) |
| abstractText | Accumulation of alpha-synuclein (alpha-syn) is the pathological hallmark of alpha-synucleinopathy. Rapid eye movement (REM) sleep behavior disorder (RBD) is a pivotal manifestation of alpha-synucleinopathy including Parkinson's disease (PD). RBD is clinically confirmed by REM sleep without atonia (RWA) in polysomnography. To accurately characterize RWA preceding RBD and their underlying alpha-syn pathology, we inoculated alpha-syn preformed fibrils (PFFs) into the striatum of A53T human alpha-syn BAC transgenic (A53T BAC-SNCA Tg) mice which exhibit RBD-like phenotypes with RWA. RWA phenotypes were aggravated by PFFs-inoculation in A53T BAC-SNCA Tg mice at 1 month after inoculation, in which prominent alpha-syn pathology in the pedunculopontine nucleus (PPN) was observed. The intensity of RWA phenotype could be dependent on the severity of the underlying alpha-syn pathology. |
