| First Author | Broxmeyer HE | Year | 2021 |
| Journal | Blood Cells Mol Dis | Volume | 90 |
| Pages | 102574 | PubMed ID | 34015674 |
| Mgi Jnum | J:331774 | Mgi Id | MGI:7398360 |
| Doi | 10.1016/j.bcmd.2021.102574 | Citation | Broxmeyer HE, et al. (2021) Expression of gilt acts as a positive regulator of mouse hematopoietic progenitor cells. Blood Cells Mol Dis 90:102574 |
| abstractText | Gamma interferon inducible lysosomal thiol reductase (GILT), is known to be involved in immunity, but its role in hematopoiesis has not been previously reported. Herein, we demonstrate using gilt knockout (-/-) mice that loss of gilt associates with decreased numbers and cycling status of femoral hematopoietic progenitor cells (CFU-GM, BFU-E, and CFU-GEMM) with more modest effects on splenic progenitor cells. Thus, GILT is associated with positive regulation of hematopoietic progenitor cells in mice, mainly in bone marrow. |
