| First Author | Hahn AM | Year | 2023 |
| Journal | Cell Rep | Volume | 42 |
| Issue | 3 | Pages | 112253 |
| PubMed ID | 36920908 | Mgi Jnum | J:342752 |
| Mgi Id | MGI:7463836 | Doi | 10.1016/j.celrep.2023.112253 |
| Citation | Hahn AM, et al. (2023) A monoclonal Trd chain supports the development of the complete set of functional gammadelta T cell lineages. Cell Rep 42(3):112253 |
| abstractText | The clonal selection theory describes key features of adaptive immune responses of B and T cells. For alphabeta T cells and B cells, antigen recognition and selection principles are known at a detailed molecular level. The precise role of the antigen receptor in gammadelta T cells remains less well understood. To better understand the role of the gammadelta T cell receptor (TCR), we generate an orthotopic TCRdelta transgenic mouse model. We demonstrate a multi-layered functionality of gammadelta TCRs and diverse roles of CDR3delta-mediated selection during gammadelta T cell development. Whereas epithelial populations using Vgamma5 or Vgamma7 chains are almost unaffected in their biology in the presence of the transgenic TCRdelta chain, pairing with Vgamma1 positively selects gammadelta T cell subpopulations with distinct programs in several organs, thereby distorting the repertoire. In conclusion, our data support dictation of developmental tropism together with adaptive-like recognition principles in a single antigen receptor. |
