| First Author | Lee J | Year | 2024 |
| Journal | Sci Adv | Volume | 10 |
| Issue | 27 | Pages | eadj4433 |
| PubMed ID | 38959322 | Mgi Jnum | J:389204 |
| Mgi Id | MGI:7663631 | Doi | 10.1126/sciadv.adj4433 |
| Citation | Lee J, et al. (2024) Phospholipase C beta 1 in the dentate gyrus gates fear memory formation through regulation of neuronal excitability. Sci Adv 10(27):eadj4433 |
| abstractText | Memory processes rely on a molecular signaling system that balances the interplay between positive and negative modulators. Recent research has focused on identifying memory-regulating genes and their mechanisms. Phospholipase C beta 1 (PLCbeta1), highly expressed in the hippocampus, reportedly serves as a convergence point for signal transduction through G protein-coupled receptors. However, the detailed role of PLCbeta1 in memory function has not been elucidated. Here, we demonstrate that PLCbeta1 in the dentate gyrus functions as a memory suppressor. We reveal that mice lacking PLCbeta1 in the dentate gyrus exhibit a heightened fear response and impaired memory extinction, and this excessive fear response is repressed by upregulation of PLCbeta1 through its overexpression or activation using a newly developed optogenetic system. Last, our results demonstrate that PLCbeta1 overexpression partially inhibits exaggerated fear response caused by traumatic experience. Together, PLCbeta1 is crucial in regulating contextual fear memory formation and potentially enhancing the resilience to trauma-related conditions. |
