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Publication : Spontaneous expression of interferon genes in murine peritoneal macrophages: modulation during the in vitro aging.

First Author  Conti L Year  1992
Journal  Arch Gerontol Geriatr Volume  15 Suppl 1
Pages  123-8 PubMed ID  18647682
Mgi Jnum  J:12212 Mgi Id  MGI:60462
Doi  10.1016/s0167-4943(05)80012-3 Citation  Conti L, et al. (1992) Spontaneous expression of interferon genes in murine peritoneal macrophages: modulation during the invitro aging. Arch Gerontol Geriatr Suppl 15 Suppl 1:123-28
abstractText  The expression of interferon (IFN)-beta gene and its modulation during in vitro "aging" was studied in unstimulated peritoneal macrophages (PM) explanted from lipopolysaccharide (LPS)-responsive (Lps(h)) and LPS-hyporesponsive (Lps(d)) mice. A strong direct correlation between the LPS response of PM and their capacity to express low levels of IFN-beta was found. Moreover, the decay of antiviral state during in vitro cultivation was correlated with the turnover of IFN-beta mRNA. In the light of the multiple biologic effect of IFN, the constitutive expression of IFN-beta gene in PM can play a crucial role not only in the restriction of viral replication, but also in the modulation of cell differentiation and immune response.
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