First Author | Conti L | Year | 1992 |
Journal | Arch Gerontol Geriatr | Volume | 15 Suppl 1 |
Pages | 123-8 | PubMed ID | 18647682 |
Mgi Jnum | J:12212 | Mgi Id | MGI:60462 |
Doi | 10.1016/s0167-4943(05)80012-3 | Citation | Conti L, et al. (1992) Spontaneous expression of interferon genes in murine peritoneal macrophages: modulation during the invitro aging. Arch Gerontol Geriatr Suppl 15 Suppl 1:123-28 |
abstractText | The expression of interferon (IFN)-beta gene and its modulation during in vitro "aging" was studied in unstimulated peritoneal macrophages (PM) explanted from lipopolysaccharide (LPS)-responsive (Lps(h)) and LPS-hyporesponsive (Lps(d)) mice. A strong direct correlation between the LPS response of PM and their capacity to express low levels of IFN-beta was found. Moreover, the decay of antiviral state during in vitro cultivation was correlated with the turnover of IFN-beta mRNA. In the light of the multiple biologic effect of IFN, the constitutive expression of IFN-beta gene in PM can play a crucial role not only in the restriction of viral replication, but also in the modulation of cell differentiation and immune response. |