| First Author | Moroy T | Year | 1996 |
| Journal | Cell Physiol Biochem | Volume | 6 |
| Issue | 6 | Pages | 312-336 |
| Mgi Jnum | J:38043 | Mgi Id | MGI:85435 |
| Doi | 10.1159/000154836 | Citation | Moroy T, et al. (1996) Regulators of life and death: The Bcl-2 gene family. Cell Physiol Biochem 6(6):312-336 |
| abstractText | Bcl-2 had been discovered by analysing a chromosomal breakpoint characteristic for a specific human cancer, Its activity as an inhibitor of programmed cell death has considerably refined our concept how malignant neoplastic conditions develop, As Bcl-2 turns out to be just one member of a large family of proteins that inhibit or accelerate apoptosis, we are now beginning to see a complex network of cellular factors emerge that regulates tissue homeostasis, The heart of this network appears to be built on the Bcl-2 family members but it also involves proteases, the regulation of ion fluxes, membrane stability and possibly cell cycle regulation to fulfill its tasks. The considerable efforts that are currently made to decipher all the rules and building blocks of this apoptosis network might soon pave the way for new strategies to efficiently fight human malignant diseases. |
