| First Author | Cosway EJ | Year | 2023 |
| Journal | Nat Commun | Volume | 14 |
| Issue | 1 | Pages | 7201 |
| PubMed ID | 37938566 | Mgi Jnum | J:342388 |
| Mgi Id | MGI:7547826 | Doi | 10.1038/s41467-023-43072-x |
| Citation | Cosway EJ, et al. (2023) The alarmin IL33 orchestrates type 2 immune-mediated control of thymus regeneration. Nat Commun 14(1):7201 |
| abstractText | As the primary site of T-cell development, the thymus dictates immune competency of the host. The rates of thymus function are not constant, and thymus regeneration is essential to restore new T-cell production following tissue damage from environmental factors and therapeutic interventions. Here, we show the alarmin interleukin (IL) 33 is a product of Sca1(+) thymic mesenchyme both necessary and sufficient for thymus regeneration via a type 2 innate immune network. IL33 stimulates expansion of IL5-producing type 2 innate lymphoid cells (ILC2), which triggers a cellular switch in the intrathymic availability of IL4. This enables eosinophil production of IL4 to re-establish thymic mesenchyme prior to recovery of thymopoiesis-inducing epithelial compartments. Collectively, we identify a positive feedback mechanism of type 2 innate immunity that regulates the recovery of thymus function following tissue injury. |
