| First Author | Bernard-Bloch R | Year | 2023 |
| Journal | J Leukoc Biol | Volume | 114 |
| Issue | 3 | Pages | 205-211 |
| PubMed ID | 37013690 | Mgi Jnum | J:342672 |
| Mgi Id | MGI:7550546 | Doi | 10.1093/jleuko/qiad040 |
| Citation | Bernard-Bloch R, et al. (2023) Ambivalent role of FasL in murine acute graft-versus-host-disease. J Leukoc Biol 114(3):205-211 |
| abstractText | Fas ligand is increased in several immune-mediated diseases, including acute graft-versus-host disease, a donor cell-mediated disorder post-hematopoietic stem cell transplantation. In this disease, Fas ligand is involved in T-cell-mediated damage to host tissues. However, the role of its expression on donor non-T cells has, so far, never been addressed. Using a well-established CD4- and CD8-mediated graft-versus-host disease murine model, we found that precocious gut damage and mice mortality are increased with a graft of donor T- and B-depleted bone marrow cells devoid of Fas ligand as compared with their wild-type counterparts. Interestingly, serum levels of both soluble Fas ligand and IL-18 are drastically reduced in the recipients of Fas ligand-deficient grafts, indicating that soluble Fas ligand stems from donor bone marrow-derived cells. In addition, the correlation between the concentrations of these 2 cytokines suggests that IL-18 production arises through a soluble Fas ligand-driven mechanism. These data highlight the importance of Fas ligand-dependent production in IL-18 production and in mitigating acute graft-versus-host disease. Overall, our data reveal the functional duality of Fas ligand according to its source. |
