| First Author | Wu M | Year | 2024 |
| Journal | Exp Cell Res | Volume | 434 |
| Issue | 1 | Pages | 113870 |
| PubMed ID | 38049082 | Mgi Jnum | J:344736 |
| Mgi Id | MGI:7567138 | Doi | 10.1016/j.yexcr.2023.113870 |
| Citation | Wu M, et al. (2023) miR-130b regulates B cell proliferation via CYLD-mediated NF-kappaB signaling. Exp Cell Res 434(1):113870 |
| abstractText | Previous studies have revealed that B cell activation is regulated by various microRNAs(miRNAs). However, the role of microRNA-130b regulating B cell activation and apoptosis is still unclear. In the present study, we first found that the expression of miR-130b was the lowest in Pro/Pre-B cells and the highest in immature B cells. Besides, the expression of miR-130b decreased after activation in B cells. Through the immuno-phenotypic analysis of miR-130b transgenic and knockout mice, we found that miR-130b mainly promoted the proliferation of B cells and inhibited B cell apoptosis. Furthermore, we identified that Cyld, a tumor suppressor gene was the target gene of miR-130b in B cells. Besides, the Cyld-mediated NF-kappaB signaling was increased in miR-130b overexpressed B cells, which further explains the enhanced proliferation of B cells. In conclusion, we propose that miR-130b promotes B cell proliferation via Cyld-mediated NF-kappaB signaling, which provides a new theoretical basis for the molecular regulation of B cell activation. |
