| First Author | Yang L | Year | 2024 |
| Journal | BMC Biol | Volume | 22 |
| Issue | 1 | Pages | 106 |
| PubMed ID | 38715001 | Mgi Jnum | J:357266 |
| Mgi Id | MGI:7638815 | Doi | 10.1186/s12915-024-01908-y |
| Citation | Yang L, et al. (2024) Temporal landscape and translational regulation of A-to-I RNA editing in mouse retina development. BMC Biol 22(1):106 |
| abstractText | BACKGROUND: The significance of A-to-I RNA editing in nervous system development is widely recognized; however, its influence on retina development remains to be thoroughly understood. RESULTS: In this study, we performed RNA sequencing and ribosome profiling experiments on developing mouse retinas to characterize the temporal landscape of A-to-I editing. Our findings revealed temporal changes in A-to-I editing, with distinct editing patterns observed across different developmental stages. Further analysis showed the interplay between A-to-I editing and alternative splicing, with A-to-I editing influencing splicing efficiency and the quantity of splicing events. A-to-I editing held the potential to enhance translation diversity, but this came at the expense of reduced translational efficiency. When coupled with splicing, it could produce a coordinated effect on gene translation. CONCLUSIONS: Overall, this study presents a temporally resolved atlas of A-to-I editing, connecting its changes with the impact on alternative splicing and gene translation in retina development. |
