| First Author | Zhang H | Year | 2008 |
| Journal | Biochem Biophys Res Commun | Volume | 366 |
| Issue | 4 | Pages | 898-904 |
| PubMed ID | 18082624 | Mgi Jnum | J:381741 |
| Mgi Id | MGI:8308958 | Doi | 10.1016/j.bbrc.2007.12.035 |
| Citation | Zhang H, et al. (2008) 0610009K11Rik, a testis-specific and germ cell nuclear receptor-interacting protein. Biochem Biophys Res Commun 366(4):898-904 |
| abstractText | Using an in silico approach, a putative nuclear receptor-interacting protein 0610009K11Rik was identified in mouse testis. We named this gene testis-specific nuclear receptor-interacting protein-1 (Tnrip-1). Tnrip-1 was predominantly expressed in the testis of adult mouse tissues. Expression of Tnrip-1 in the testis was regulated during postnatal development, with robust expression in 14-day-old or older testes. In situ hybridization analyses showed that Tnrip-1 is highly expressed in pachytene spermatocytes and spermatids. Consistent with its mRNA expression, Tnrip-1 protein was detected in adult mouse testes. Immunohistochemical studies showed that Tnrip-1 is a nuclear protein and mainly expressed in pachytene spermatocytes and round spermatids. Moreover, co-immunoprecipitation analyses showed that endogenous Tnrip-1 protein can interact with germ cell nuclear receptor (GCNF) in adult mouse testes. Our results suggest that Tnrip-1 is a testis-specific and GCNF-interacting protein which may be involved in the modulation of GCNF-mediated gene transcription in spermatogenic cells within the testis. |
