| First Author | Zerangue N | Year | 1999 |
| Journal | Neuron | Volume | 22 |
| Issue | 3 | Pages | 537-48 |
| PubMed ID | 10197533 | Mgi Jnum | J:390898 |
| Mgi Id | MGI:8399830 | Doi | 10.1016/s0896-6273(00)80708-4 |
| Citation | Zerangue N, et al. (1999) A new ER trafficking signal regulates the subunit stoichiometry of plasma membrane K(ATP) channels. Neuron 22(3):537-48 |
| abstractText | Proper ion channel function often requires specific combinations of pore-forming alpha and regulatory beta subunits, but little is known about the mechanisms that regulate the surface expression of different channel combinations. Our studies of ATP-sensitive K+ channel (K(ATP)) trafficking reveal an essential quality control function for a trafficking motif present in each of the alpha (Kir6.1/2) and beta (SUR1) subunits of the K(ATP) complex. We show that this novel motif for endoplasmic reticulum (ER) retention/retrieval is required at multiple stages of K(ATP) assembly to restrict surface expression to fully assembled and correctly regulated octameric channels. We conclude that exposure of a three amino acid motif (RKR) can explain how assembly of an ion channel complex is coupled to intracellular trafficking. |
